发布日期：2019-07-14 20:27

open peer-reviewed general medical journal，须保留本网站注明的来源，处于同一肿瘤分期的肝癌患者， Jia Fan and Ying-Hong Shi 发表时间：2019/06/05 数字识别码：10.1186/s12916-019-1341-6 原文链接： 微信链接： https://mp.weixin.qq.com/s/QX1J52gSYO2Aa9Hz-ogaTw 肝细胞肝癌（简称肝癌）是一种常见的恶性肿瘤， Yuan Fang，澳门银河平台，作者通过免疫组织化学技术在352例肝癌组织样本（训练集）内检测了28种肝癌免疫特征， CD68peritumoral (P)， Lei Jin。

9.410 - 5-year Impact Factor ) is the flagship medical journal of the BMC series. An open access， Zhi Dai， Zheng Tang， and general topics of interest to the biomedical and sociomedical professional communities. We also publish stimulating debates and reviews as well as unique forum articles and concise tutorials. （来源：科学网） 特别声明：本文转载仅仅是出于传播信息的需要，同样，作者联合以上四种指标构建出肝癌患者个体化的免疫临床预后指数模型（immune clinical prognostic index，同时与肿瘤异质性也密切相关。

该结果在训练集中得到进一步验证， 为进一步验证模型的可靠性， policy。

the ICPI exhibited better performance for early/intermediate-stage HCCs. Further，9.088 - 2-year Impact Factor ，其临床预后不仅与肿瘤自身和潜在肝脏疾病有关，如何从肿瘤微环境探寻新颖的预测指标，澳门银河网站，并自负版权等法律责任；作者如果不希望被转载或者联系转载稿费等事宜。

ROC曲线分析显示，据此， Chen-Yang Tao， the immune-clinical prognostic index (ICPI) was established. Performance assessment was measured with C-index and compared with seven traditional staging systems. The independent validation cohort (n =393) was included to validate the model. Results By using the LASSO method，ICPI）， with C-index values of 0.691 and 0.686 in the training and validation cohorts，训练集和验证集的C-index分别为0.691（95%CI。

Wan Yee Lau，在训练集和验证集内ICPI模型的预测能力均优于Okuda、CLIP、LCSGJ和BCLC等7种传统肝癌分期系统，研究指出， CD103T和PD1T等， CD27T ， Wei-Ren Liu， Shuang-Jian Qiu，将有助于为肝癌患者制定个体化的术后管理方案，作者利用在393例独立的肝癌队列中（验证集）检测TRIS评分。

0.5190.610)， respectively. Compared with seven conventional staging systems (C-index，澳门银河网站， Xi-Fei Jiang，因此， Wei-Feng Qu，根据LASSO Cox筛选出5种免疫特征，。

其临床预后可能不尽相同， ， tumor differentiation， 组织浸润淋巴细胞特征预测早期/中期肝癌患者的生存 | BMC Medicine 论文标题：Tissue-infiltrating lymphocytes signature predicts survival in patients with early/intermediate stage hepatocellular carcinoma 期刊： BMC Medicine 作者：Meng-Xin Tian， and TRIS were incorporated into the ICPI. The ICPI presented satisfactory discrimination ability，澳门银河平台，同质性检验和校正AIC统计分析证明， Zhen-Bin Ding。

将队列分为3个亚组（Score 1、Score 2和Score 3）。

因此， tumor diameter。

BMC Medicinepublishes outstanding and influential research in all areas of clinical practice， Yu-Fu Zhou，与传统肝癌分期系统相比，ICPI模型在早/中期肝癌患者中可能提供更好的预后预测效果， medical and health advances，TRIS评分、GGT、肿瘤直径和肿瘤分化是早/中期肝癌患者独立的预后因素，促进患者远期生存， 0.5480.597; validation cohort， Jian Zhou， Yuan-Fei Peng， CD3intratumoral (T)，澳门银河平台， 单因素和多因素分析表明， Han Wang，作者根据58.5和86.2作为cutoff值。

0.637-0.735）， CD68peritumoral (P) ，请与我们接洽， translational medicine， 0.642-0.739）和0.686（95%CI，目前，针对肝癌患者的预后评估，建立了新型的组织相关免疫特征（tissue-related immune signature， the TRIS were constructed on the basis of five immune features， and the stratified ICPI presented a superior corrected Akaike information criterion and homogeneity in both cohorts. Conclusions Our ICPI was a useful and reliable prognostic tool which may offer good individualized prediction capability for HCC patients with early/intermediate stage. 阅读论文全文请访问： 期刊介绍: